Published on Friday, 05 August 2016
Abstract
Melatonin is considered to be a mysterious substance in human body which is secreted by pineal gland in night mainly and has a variety of physiological functions and plays significant role in the pathophysiology of many diseases.
Apart from its own antioxidative effect melatonin also intensifies the activity of endogenous antioxidative enzymes, which collectively potentiate cytoprotective and free radical scavenging activities.
Melatonin may play a protective role against oxidation disorders of cerebral nerve cells during nocturnal sleep as it easily crosses blood brain barrier.
Melatonin acts as a radical free scavenger and has indirect actions to detoxify carcinogens by activating the glutathione and antioxidative pathways, protecting the cells from DNA damage and also by repairing the DNA if certain damage has occurred.
It is well documented that melatonin has cytoprotective and free radical scavenger activities therefore present review study is an attempt to link the mechanism of inhibition of initiation and progression of cancer by melatonin within human body.
NOTE: This publication cites (Ref. N.8): Di Bella G., Mascia F., Gualano L., Di Bella L. - Melatonin anticancer effect: review. Int J Mol Sci. 2013;14:2410–2430.
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See also
- About Melatonin;
- Evaluation of the safety and efficacy of the first-line treatment with somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide in 20 cases of breast cancer: a preliminary report;
- The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 122 cases of breast cancer;
- Complete objective response to biological therapy of plurifocal breast carcinoma;
- Recurrent Glioblastoma Multiforme (grade IV – WHO 2007): a case of complete objective response achieved by means of the concomitant administration of Somatostatin and Octreotide – Retinoids – Vitamin E – Vitamin D3 – Vitamin C – Melatonin – D2 R agonists (Di Bella Method – DBM) associated with Temozolomide;
- The Di Bella Method DBM improved survival objective response and performance status in a retrospective observational clinical study on 23 tumours of the head and neck;
- Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in advanced non-small-cell lung cancer patients with low performance status;
- Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in chemotherapy-pretreated patients with advanced lung adenocarcinoma and low performance status;
- Observations on the Report of a case of pulmonary adenocarcinoma with lymph node, hepatic and osseus metastasis;
- Neuroblastoma: Complete objective response to biological treatment;
- The Di Bella Method (DBM) in the treatment of prostate cancer: a preliminary retrospective study of 16 patients and a review of the literature.
