Somatostatin receptors expression (SSTR1-SSTR5) in pheochromocytomas

Abstract

Confirmation of somatostatin receptors (SSTR) expression in neuroendocrine tumours has changed their modern diagnosis and therapy, and starts to influence the approach to pheochromocytomas.

In vitro studies have revealed the SSTR expression in pheochromocytomas, particularly subtype 2A and 3. They also have indicated that their confinement to cell membranes is essential for successful diagnostics with the use of somatostatin analogues.

Scintigraphy with radiolabeled somatostatin analogues is nowadays an approved complementary method of pheochromocytoma localization, particularly the malignant ones.

Cell culture studies have indicated that the commercially available somatostatin analogues are able to control tumour growth and secretion. Unfortunately these results have not been confirmed by clinical studies.

It seems that the analogues with the broader affinity to sstr may be a good therapeutic option for pheochromocytoma patients. Promising results of radiotherapy with labeled analogues have been recently announced.

About this publication.

See also:

- Official Web Site: The Di Bella Method;

- The Di Bella Method (A Fixed Part - Somatostatin, Octreotide, Sandostatin LAR, analogues and/or derivatives);

- Somatostatin in oncology, the overlooked evidences - In vitro, review and in vivo publications;

- Publication, 2018 Jul: Over-Expression of GH/GHR in Breast Cancer and Oncosuppressor Role of Somatostatin as a Physiological Inhibitor (from Di Bella's Foundation);

- Publication, 2018 Sep: The over-expression of GH/GHR in tumour tissues with respect to healthy ones confirms its oncogenic role and the consequent oncosuppressor role of its physiological inhibitor, somatostatin: a review of the literature (from Di Bella's Foundation);

- Publication, 2019 Aug: The Entrapment of Somatostatin in a Lipid Formulation: Retarded Release and Free Radical Reactivity (from Di Bella's Foundation);

- Publication, 2019 Sep: Effects of Somatostatin and Vitamin C on the Fatty Acid Profile of Breast Cancer Cell Membranes (from Di Bella's Foundation);

- Publication, 2019 Sep: Effects of somatostatin, curcumin, and quercetin on the fatty acid profile of breast cancer cell membranes (from Di Bella's Foundation);

- Publication, 2020 Sep: Two neuroendocrine G protein-coupled receptor molecules, somatostatin and melatonin: Physiology of signal transduction and therapeutic perspectives (from Di Bella's Foundation);

- The Di Bella Method (A Fixed Part - Bromocriptine and/or Cabergoline);

- The Di Bella Method (A Fixed Part - Cyclophosphamide 50mg tablets and/or Hydroxyurea 500mg tablets, one or two per day);

- Pancreatic Adenocarcinoma: clinical records on 17 patients treated with Di Bella's Method;

- The Di Bella Method Increases by the 30% the survival rate for Pancreas tumors and for this reason should be proposed as first line therapy for this type of cancer;

- Neuroblastoma: Complete objective response to biological treatment;

- Oesophageal squamocellular carcinoma: a complete and objective response.