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PROMISING COMPOUNDS WITH HEALTH BENEFITS: PHYTOMELATONIN AND MELATONIN

Published on Thursday, 05 November 2026

Abstract

Objective: Melatonin is a molecule naturally found in living organisms and has antioxidant, anticancer, and anti-inflammatory activities. Phytomelatonin, the plant-based derivative of the hormone melatonin, is a naturally occurring compound in plants that plays a role in growth, stress tolerance, and environmental adaptation. Melatonin and phytomelatonin are naturally found in living organisms and can also be synthesized from the essential amino acid tryptophan. Within the scope of the study, the biosynthesis pathways, plant sources, and chemical structures of melatonin and phytomelatonin were detailed, and their general effects were examined, providing information based on current literature.

Result and Discussion: Melatonin with its anticancer and anti-inflammatory effects. Phytomelatonin plays a crucial role in photosynthesis, cellular redox balance, and the regulation of secondary metabolites, exhibiting versatile effects on human health. These effects include regulating circadian rhythms, reducing oxidative stress, supporting the is an important hormone secreted by the pineal gland that plays a role in functions such as the regulation of circadian rhythm, synchronization of the biological clock, and the maintenance of homeostasis immune system, and inducing apoptosis in cancer cells. The structural and functional similarities and effects of these molecules are making them increasingly the focus of interest, and in vitro and in vivo studies will reveal their promising potential for health.

NOTE: This publication references these works:
- Reference N° 28: Di Bella, L., Scalera, G., Rossi, M.T. (1980). Melatonin: An essential factor for the treatment and recovery from leukemia and cancer. Proceedings of International Symposium on Melatonin, Bremen, Germany, 161-162;
- Reference N° 30: Di Bella G., Mascia F., Gualano L., Di Bella L. (2013) - Melatonin anticancer effect: review. Int J Mol Sci. 2013;14:2410–2430;

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- The Di Bella Method (A Fixed Part - Melatonin tablets. From 30-40mg/day up to 200mg/day and more orally in patients with advanced stage of cancer disease and/or patients without respond to traditional treatments);

- Melatonin use in cancer patients have started in 1974, when melatonin prepared according to Prof. Di Bella’s formulation [...]. For 11 days was administered to the patient, admitted to the general medical ward at the Maggiore-Pizzardi Hospital in Bologna, very slowly (over approx. 8 hours) and intravenously administered 1000 mg of melatonin for 11 days. During the course of each day, the patient was intravenously administered 4 saline drips of 500 ml, each containing ten 25 mg bottles of freeze-dried melatonin, lasting 2 hours, totaling 1000 mg per day. No other drug of any kind was administered in order to ascertain the effect of the MLT without interference [...]. From Melatonin with adenosine solubilized in water and stabilized with glycine for oncological treatment - technical preparation, effectivity and clinical findings (Di Bella's Foundation);

- About Melatonin - In vitro, review and in vivo publications;

- 2013 Jan - Publication: Melatonin anticancer effects: Review (from Di Bella's Foundation);

- 2006 Sep - Publication: Key aspects of melatonin physiology: 30 years of research (from Di Bella's Foundation);

- 1980 Sep - International Symposium on Melatonin: Melatonin: an essential factor for the treatment and recovery from leukemia and cancer (Di Bella's Foundation);

- The Di Bella Method (A Fixed Part - Vitamin C/Ascorbic Acid, 2–4 grams, twice a day orally);

- The Di Bella Method (A Fixed Part - Dihydrotachysterol, Alfacalcidol, synthetic Vitamin D3 - Preferably the blood concentration value should be around the middle between 75ng/ml and 100ng/ml);

- Vitamin D (analogues and/or derivatives) and cancer - In vitro, review and in vivo publications;

- The Di Bella Method (A Fixed Part - Alpha tocopheryl acetate/Vitamin E, approximately 20 grams per day orally);

- Cancer and Vitamin E (analogues and/or derivatives) and cancer - In vitro, review and in vivo publications;

- Solution of retinoids in vitamin E in the Di Bella Method biological multitherapy;

- The Di Bella Method (A Fixed Part - All-Trans Retinoic Acid, Analogues and/or Derivatives - Approximately 60mg per day orally: 40mg per day Beta-Carotene/β-Carotene, 10mg per day ATRA and 10mg per day Axerophthol palmitate);

- 2015 Dec - Publication: Solution of retinoids in vitamin E in the Di Bella Method biological multitherapy (from Di Bella's Foundation);

- All-Trans-Retinoic Acid (ATRA - analogues and/or derivatives) - In vitro, review and in vivo publications;

The Di Bella's Method: Use of Melatonin since 1974 - together with others chemical compounds: the dosage and administration schedule must be individualised for each patient - in several Oncological Pathologies:

- A retrospective observational clinical study of triple negative breast cancer cases treated with Di Bella Method: A preliminary data;

- The Synergism of Somatostatin, Melatonin, Vitamins Prolactin and Estrogen Inhibitors Increased Survival, Objective Response and Performance Status In 297 Cases of Breast Cancer;

- Complete objective response, stable for 5 years, with the Di Bella Method, of multiple-metastatic carcinoma of the breast;

- Evaluation of the safety and efficacy of the first-line treatment with somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide in 20 cases of breast cancer: a preliminary report;

- The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 122 cases of breast cancer;

- Complete objective response to biological therapy of plurifocal breast carcinoma;

- A retrospective observational study on cases of anaplastic brain tumors treated with the Di Bella Method: A rationale and effectiveness;

- Recurrent Glioblastoma Multiforme (grade IV – WHO 2007): a case of complete objective response achieved by means of the concomitant administration of Somatostatin and Octreotide – Retinoids – Vitamin E – Vitamin D3 – Vitamin C – Melatonin – D2 R agonists (Di Bella Method – DBM) associated with Temozolomide;

- The Di Bella Method DBM improved survival objective response and performance status in a retrospective observational clinical study on 23 tumours of the head and neck;

- Chronic Lymphocytic Leukemia: Long-Lasting Remission with Combination of Cyclophosphamide, Somatostatin, Bromocriptine, Retinoids, Melatonin, and ACTH;

- Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in advanced non-small-cell lung cancer patients with low performance status;

- Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in chemotherapy-pretreated patients with advanced lung adenocarcinoma and low performance status;